Cinnamic acids and derivatives
Medchemexpress LLC Arn 077 enantiomer | 1439366-88-7 | 99.7% | 1 MG
Arn 077 enantiomer is the less active enantiomer of ARN 077 and functions as an inhibitor of N-acylethanolamine acid amidase (NAAA); reported IC50 for rat NAAA is 3.53 μM. Supplied as a solid for research applications.
- Less active enantiomer with reported IC50 = 3.53 μM for rat NAAA.
- Chemical formula C16H21NO4; molecular weight 291.34 g/mol.
- White to off-white solid; powder storage at -20°C for long-term stability.
- High DMSO solubility (100 mg/mL); vehicle formulations reported for in vivo use at ≥ 2.5 mg/mL.
- For research use only; handle according to appropriate safety procedures.
TARGETMOL CHEMICALS INC Tyrphostin AG 528 25MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Tyrphostin AG 528 (Tyrphostin B66) is an inhibitor of EGFR (IC50 4.9 uM) and ErbB2 (IC50 2.1 uM). Purity 99.74%
Apexbio Technology LLC Tyrphostin A1 2826-26-8 25mg
Tyrphostin A1 (CAS 2826-26-8) is a small molecule inhibitor targeting tyrosine kinase activity specifically involved in disrupting intracellular signaling pathways in immune cells It has been shown to interfere with CD40 ligand-induced signaling resulting in suppressed interleukin-12 (IL-12) secretion by macrophages and reduced differentiation of antigen-induced T helper 1 (Th1) cells Tyrphostin A1 is widely utilized in studies investigating cell-to-cell signaling immune response modulation and the mechanisms underlying inflammatory processes particularly in the context of autoimmune disease models
Medchemexpress LLC Tyrphostin AG 528 | 133550-49-9 | MFCD01076474 | 98.0% | 306.32 g/mol | C18H14N2O3 | 5 MG
Tyrphostin AG 528 is a small-molecule tyrosine kinase inhibitor of EGFR and ErbB2 used in preclinical research to probe receptor signaling. It is supplied as a purified research chemical for in vitro and exploratory studies; chemical formula C18H14N2O3, molecular weight 306.32 g/mol, purity 98.0%.
- Potent inhibitor of EGFR and ErbB2 with reported IC50s of 4.9 μM and 2.1 μM.
- High purity suitable for biochemical and cellular assays.
- Available in small quantities appropriate for dose-response studies.
- Contains the CAS number 133550-49-9 for unambiguous identification.
- Supplied with a manufacturer datasheet detailing physicochemical properties and handling.
Medchemexpress LLC (2E,4E)-Hepta-2,4-dienal | 4313-03-5 | 90.6% | 110.16 | 5 G
(2E,4E)-Hepta-2,4-dienal is a biochemical reagent that can be used as a biological material or organic compound for life science related research. It is for research use only and not sold to patients.
- Can be used as a biological material or organic compound for life science related research
- For research use only
- Not sold to patients
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 5 MG
Medchemexpress LLC Tyrphostin AG 112 | 144978-82-5 | 98.3% | 236.23 | 10 MG
Tyrphostin AG 112 is an EGFR phosphorylation inhibitor, intended for research use only.
- Inhibits EGFR phosphorylation.
- Detailed solubility information for in vitro and in vivo applications is available.
- Comprehensive documentation including Data Sheet, COA, SDS, HNMR, LCMS, and Handling Instructions.
- Target: EGFR.
- Pathway: JAK/STAT Signaling; Protein Tyrosine Kinase/RTK.
![Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402443-logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG
Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, showing at least 500-fold higher selectivity for ErbB2 over EGFR. This compound exhibits anticancer activity.
- Significantly decreases cell proliferation in various cell lines
- Induces a dose-dependent increase in apoptosis
- Reduces tumor sizes in animal models
Medchemexpress LLC Curcumin 5-8 | 890984-26-6 | 98.58% | 339.39 | 100 MG
Curcumin 5-8 is a potent, orally active curcumin analog. It inhibits lipid droplet formation, increases autophagy, and inhibits apoptosis. It also improves insulin resistance and insulin sensitivity, and has been shown to ameliorate nonalcoholic fatty liver disease in mice.
- Decreases PA-induced SREBP1 expression and increases Bcl2/BAX expression in AML12 cells.
- Exhibits cytotoxic activity against B16, HUVEC, SiHa, U-87MG ATCC, and Vero cell lines.
- Ameliorates insulin resistance and hepatic steatosis in HFD-induced obese mice.
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Tyrphostin A1 | 2826-26-8 | 98.96% | 184.19 | 1 ML
Medchemexpress LLC Tyrphostin A1 | 2826-26-8 | 99.0% | 184.19 | 25 MG
Tyrphostin A1 (AG9) is a compound that inhibits CD40L-stimulated IL-12 production and antigen-induced generation of Th1 cells. It blocks CD40L-induced translocation of NF-κB to the nucleus, reducing IL-12 p40 gene activation. In vivo, it decreases the generation of myelin basic protein (MBP) specific encephalitogenic T cells and attenuates experimental allergic encephalomyelitis (EAE).
- Inhibits CD40L-stimulated IL-12 production in macrophage cultures
- Inhibits antigen-induced generation of Th1 cells
- Blocks CD40L-induced translocation of NF-κB to the nucleus
- Reduces activation of the IL-12 p40 gene
- Decreases generation of myelin basic protein (MBP) specific encephalitogenic T cells
- Attenuates experimental allergic encephalomyelitis (EAE)
- Differentiates TK-mediated effects from non-specific effects due to weak TK inhibition (IC50>1250 μM for epidermal growth factor receptor (EGFR) kinase)
Medchemexpress LLC (4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one | 100667-52-5 | 97.0% | 280.36 g/mol | C19H20O2 | 5 MG
(4E)-7-(4-hydroxyphenyl)-1-phenylhept-4-en-3-one is a diarylheptanoid small-molecule for laboratory research and analytical applications. The compound is supplied as a solid with molecular formula C19H20O2, molecular weight 280.36 g/mol, and an analytical purity of 97.0% (NMR). Store protected from light at low temperatures; consult the certificate of analysis for batch-specific handling and stability information.
- Solid, white to off-white appearance.
- Molecular formula C19H20O2.
- Molecular weight 280.36 g/mol.
- Analytical purity 97.0% (NMR).
- Storage: keep container tightly sealed, protect from light; recommended -20°C for solid, in solvent -80°C for 6 months or -20°C for 1 month.
- Intended for research and analytical use only; not for human therapeutic use.
Medchemexpress LLC (2E,4E)-Hepta-2,4-dienal | 4313-03-5 | 90.6% | 110.16 | 10 G
(2E,4E)-Hepta-2,4-dienal is a naturally occurring organic compound belonging to the group of aldehydes. It is an unsaturated aldehyde with two conjugated double bonds, giving it unique chemical and physical properties. It is commonly found in various plant sources, especially in spices such as parsley and coriander. It can be used as a biological material or organic compound for life science related research.
- Biochemical reagent for life science related research
- Naturally occurring organic compound
- Found in plant sources like parsley and coriander
- Used as a flavoring agent and food additive
- Also used in the fragrance industry
![Medchemexpress LLC 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile | 118409-58-8 | MFCD00133900 | 99.0% | 202.17 g/mol | C10H6N2O3 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000247987.png-250.jpg)
Medchemexpress LLC 2-[(3,4,5-trihydroxyphenyl)methylidene]propanedinitrile | 118409-58-8 | MFCD00133900 | 99.0% | 202.17 g/mol | C10H6N2O3 | 5 MG
Tyrphostin 25 (AG82) is a small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that also acts as a GPR35 agonist. It is commonly used in cell signaling and pharmacology research; reported activities include EGFR inhibition (IC50 ≈ 3 μM in A431 cells) and GPR35 activation (EC50 ≈ 5.3 μM).
- Selective EGFR tyrosine kinase inhibition for cell signaling and migration studies.
- GPR35 agonist activity supports investigation of alternative GPCR-mediated pathways.
- High purity (~99.0%) suitable for biochemical and cellular assays.
- Solid, yellow-brown material with molecular weight 202.17 and formula C10H6N2O3.
- Recommended storage: powder at -20°C (stable ~3 years); in solvent store at -80°C for long-term stability.